Work 07 of 9 · Playbook H
Aster Bio
Engineering cellular resilience against age-related disease.
- Playbook
- H · Deep tech & science
- Variant
- H · Organic science
- Loud idea
- Tri-color full-bleed pillars
- Type
- Manrope 400 · Manrope 400 · Geist Mono
Preclinical biotech
Engineering cellular resilience against age-related disease.
Small molecules that restore how aged cells respond to stress. Our lead program, AST-201, begins IND-enabling studies in 2027.
Explore the platformPlatform
Three steps from aging biology to a medicine.
We start from human aging data, not a single target. Every program moves through the same three stages, in this order.
Cellular atlas
We profile 2.4 million aged human cells across 14 tissues to find where stress responses fail first.
Molecule design
A structure-guided chemistry platform designs small molecules that restore those responses, and only those.
Translational models
Candidates are tested in human organoids and aged mouse cohorts before a single patient is dosed.
Publications
Peer-reviewed, and published in full.
Our datasets and methods go out with every paper, so other labs can check the work.
Peer-reviewed
A small-molecule eIF2B activator restores stress recovery in aged human fibroblasts
Aging Mechanisms · Okonkwo R, Lindqvist M, Rao P, et al.
doi:10.5555/ast.2026.0806Peer-reviewed
A single-cell atlas of stress-response decline across 14 human tissues
Cell Resilience Reports · Rao P, Adeyemi K, Moreau L, et al.
doi:10.5555/ast.2026.0318Preprint
AST-201 preserves cardiac function in 24-month-old mice without weight loss
Molecular Gerontology Letters · Lindqvist M, Hart E, Chen Y, et al.
doi:10.5555/ast.2025.1120
Brief
What it had to do.
- Subject
- A biotech developing small-molecule therapeutics for aging.
- Audience
- Scientists, investors and prospective hires.
- Job
- Understand the platform, then work with the team.
- Proof
- Named programs, publications and a clear pipeline.
Token plan
Written before any code.
design.md’s Agent Protocol asks for this table first. Ratios are WCAG 2, measured on the surface each color actually sits on.
| Color | Hex | Role | Contrast |
|---|---|---|---|
| Off-white | #F7F7F5 | Page | — |
| Charcoal | #222F30 | Ink, primary | 12.90:1 |
| Body | #50595A | Body text | 6.71:1 |
| Sage dim | #8A8D7E | Headline tail, ≥ 24px only | 3.16:1 |
| Soft mint | #CEF79E | Pillar, arrow tiles | 11.48:1 with ink |
| Stone | #E7E8E1 | Pillar | — |
Decisions
Why it looks this way.
- 01
Weight 400 everywhere at −0.02em; hierarchy comes from size alone, as on Integrated Bio.
- 02
The three full-bleed pillars are the loud idea; the split CTA and notched cards use their quiet fallbacks.
- 03
The dimmed headline tail is #8A8D7E (3.16:1 at ≥ 24px) — the reference's #C9CBBE measures 1.53:1.
- 04
Mono uppercase labels mark real categories and dates only, one per section.